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Target intelligence / Profile preview
Nuclear pore complex interacting protein family member B3 (NPIPB3)
- Target
- NPIPB3
- Molecular classification
- Other (primate-specific nuclear pore complex-interacting protein family)
01
Overview
Nuclear pore complex interacting protein family member B3 (NPIPB3) is a protein-coding gene belonging to a primate-specific family of nuclear pore complex-interacting proteins. It is predicted to localize to the nuclear envelope and may play a role in nuclear envelope function, as well as potentially participating in cellular immune responses to viral proteins, such as SARS-CoV-2 open reading frame 6. There are few characterized biological or therapeutic roles, and little direct evidence supporting its use or modulation as a clinical drug target[1][3][5][8].
- Other names
- NPIPL3KIAA0220Nuclear pore complex-interacting protein family member B3Nuclear pore complex-interacting protein-like 3Protein pps22-1
02
Biological functions
Potential involvement in nuclear envelope dynamicsMay have a role in host-virus interactions and innate immune response
03
Disease associations
Other (reported association with frontal sinusitis and SARS-CoV-2 interferon response)
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