Nuclear pore complex interacting protein family member B5 (NPIPB5)

Nuclear pore complex interacting protein family member B5 (NPIPB5) is a protein-coding gene found in humans (gene ID 100132247) and encodes a predicted protein potentially associated with the nuclear pore complex (NPC), which is a large protein assembly responsible for transport between the nucleus and cytoplasm. NPIPB5 is detected at the transcriptomic level in a variety of tissues, and somatic mutations in NPIPB5 have been observed in several cancer types, though its function is not well understood and it is not currently established as a clinically relevant therapeutic target. There are no known drugs, biomarker roles, or safety concerns linked to NPIPB5 at this time. The broader family of nuclear pore complex proteins (nucleoporins) is essential for cellular transport and genome stability, but the specific contribution of NPIPB5 remains undefined. Key points: - Not a classical therapeutic target: It is not classified as a receptor, enzyme, transporter, or canonical drug target and is not currently implicated directly in therapeutic strategies. - Limited functional data: The gene is annotated as protein-coding; mutational analyses hint at possible relevance to malignancy, but functional significance is unknown. - Disease associations are preliminary: Somatic mutations are found in tumors, but causality and mechanistic roles remain unproven. - No approved drugs, biomarkers, or safety issues: No clinical or pre-clinical use is currently known.

Other names

NPIPB5Nuclear pore complex-interacting protein family member B5Nuclear pore complex interacting protein related

None known