Nuclear pore complex protein Nup153 (NUP153)

Nuclear pore complex protein Nup153 (NUP153) is an essential nucleoporin located in the basket structure on the nuclear side of the nuclear pore complex in vertebrates[2]. It serves as an anchoring point for the nuclear pore, acts as a docking site for karyopherins (transport proteins), and contains three main regions: an N-terminal pore targeting and RNA-binding domain, a central region with zinc finger motifs (Ran-GDP binding), and a C-terminal region with XFXFG repeats for receptor docking and Lamin B binding[4][7]. NUP153 plays key roles in the regulation of nucleocytoplasmic transport, chromatin architecture (by interacting with CTCF and cohesin[1]), cell cycle regulation (mitotic progression and nuclear structure[3]), and export of multiple cargo classes including RNA and proteins such as the HIV Rev protein[5]. It also facilitates efficient transcriptional responses for developmental genes and participates in DNA damage response by promoting import of 53BP1[6]. Its loss disrupts nuclear pore assembly, mitotic checkpoint regulation, and proper RNA/protein export, contributing to various disease states, chiefly cancer and restrictive dermopathy[7][1][5]. There are no drugs directly targeting NUP153, and its essential cellular role means that safety concerns preclude its use as a pharmacological target.

Other names

Nup153HNUP153N153153 kDa nucleoporinNucleoporin 153kDaNuclear pore complex protein hnup153Nucleoporin Nup153NUP153

None established for drugs, as NUP153 is not a classical drug target. Some RNAs, proteins (e.g., HIV Rev), and nuclear transport modulators functionally interact with NUP153 by binding or relying on its export or import activity, but no drug directly targets it[5].