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Nuclear pore complex protein Nup155 (Nup155)
- Target
- Nup155
- Molecular classification
- Scaffold protein, Component of nuclear pore complex, Nucleoporin, Other (not a receptor, ion channel, enzyme, transporter, or transcription factor)
01
Overview
Nuclear pore complex protein Nup155 is an essential, conserved structural protein that forms part of the nuclear pore complex (NPC) in eukaryotic cells. It localizes symmetrically at both the nucleoplasmic and cytoplasmic sides of the NPC, where it interacts with other nucleoporins (e.g., Nup35, Nup93) and supports the assembly and maintenance of the nuclear pore and nuclear envelope. Nup155 is indispensable for nuclear membrane fusion, chromosomal segregation, and for the regulated transport of macromolecules such as mRNA and proteins between the nucleus and cytoplasm. Mutations or depletion lead to defects in mitosis, chromosome segregation, and embryogenesis, and it has indirect roles in cell cycle control through its impact on mRNA translation and the p53 network. There are currently no reported drugs or biomarkers directly involving Nup155, but its disruption is lethal and associated with disease.
- Other names
- NUP155Nuclear pore complex protein Nup155KIAA0791N155155 kDa nucleoporinNucleoporin Nup155ATFB15nucleoporin Nup155nucleoporin 155kD/155kDa
02
Mechanism of action
None reported (no drugs directly target Nup155)
03
Biological functions
Nuclear pore complex assemblyNuclear envelope formation and maintenanceRegulation of nucleocytoplasmic transport (mRNA, protein)Chromosome segregation during mitosisRNA transport and quality control in postmitotic cellsPossibly mRNA translation regulation
04
Disease associations
Cancer (especially, implicated in liver cancer and possibly other neoplasms via p53-related pathway dysfunction)Cardiovascular disease (mutations implicated in atrial fibrillation and related cardiac conditions)Other (potential roles in developmental disorders via embryogenesis defects)
05
Safety considerations
Null (no drugs target Nup155; theoretical safety concern would be disruption of nuclear envelope and nucleocytoplasmic transport, resulting in cell death)
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