Nuclear pore complex protein Nup160 (NUP160)

Nuclear pore complex protein Nup160 (NUP160) is a structural component of the nuclear pore complex (NPC), specifically part of the Nup107–Nup160 subcomplex, which forms part of the outer ring scaffold of the NPC[1][2]. The NPC mediates macromolecular trafficking between the nucleus and cytoplasm of eukaryotic cells. Nup160 plays essential roles in nuclear–cytoplasmic transport (particularly mRNA export), mitotic spindle formation, chromosome segregation, and maintaining genome integrity[2]. Mutations in NUP160 are implicated in nephrotic syndrome type 19, including hereditary steroid-resistant forms[1][4]. Loss of Nup160 disrupts nuclear pore structure and function and leads to aberrant nuclear architecture and cellular defects[4]. NUP160 is essential for cellular and organismal viability, and its dysfunction can result in severe developmental or physiological abnormalities. There are currently no known clinically approved drugs targeting NUP160.

Other names

Nucleoporin 160KIAA0197NUP120FLJ22583160 kDa nucleoporinNucleoporin Nup160NPHS19nucleoporin 160kDnucleoporin 160kDa