Nuclear pore complex protein Nup214 (NUP214)

Nuclear pore complex protein Nup214 (NUP214) is a critical FG-repeat-containing nucleoporin localized to the cytoplasmic face of the nuclear pore complex in human cells. It plays an essential role in nucleocytoplasmic transport, serving as a docking site for receptor-mediated import and export of macromolecules, and is necessary for proper cell cycle progression and mRNA export. NUP214 is notable for its involvement in disease, particularly as part of the DEK-NUP214 fusion gene, which arises from a t(6;9) chromosomal translocation in certain leukemias[1][5]. The protein interacts with several transport factors including DDX19, CRM1, NXF1, and NXF2, participating in remodeling of messenger ribonucleoprotein particles (mRNPs) during their export from the nucleus to the cytoplasm[1][2][3]. Given its essential cellular functions and disease linkages, NUP214 is investigated as a prospective therapeutic target but poses significant challenges due to its fundamental cellular roles and potential toxicity upon inhibition[6].

Other names

CAINCANKIAA0023D9S46EN214214 kDa nucleoporinProtein CANNucleoporin Nup214CAN proteinputative oncogeneIIAE9nucleoporin 214kDa

Modulation of nucleocytoplasmic transport pathways; Potential disruption or targeting of protein-protein interactions (e.g., with DDX19, CRM1); Targeting oncogenic fusion products (e.g., DEK-NUP214 fusion in leukemia)