Nuclear pore complex protein Nup85 (NUP85)

Nuclear pore complex protein Nup85 (NUP85) is a scaffold protein that forms part of the Nup107-160 (Y-complex) subcomplex within the nuclear pore complex (NPC), an essential structure embedded in the nuclear envelope responsible for bidirectional transport of macromolecules between the cytoplasm and nucleus[1][2][4][6]. Nup85 participates in nucleocytoplasmic transport, spindle assembly during mitosis, chromatin organization, and RNA export[1][4][5][6]. It also contributes to monocyte chemotaxis by interacting with the chemokine receptor CCR2, mediating cellular response to inflammation[1]. Genetic variants in NUP85 are associated with nephrotic syndrome (type 17), primary microcephaly, intellectual disability, and Seckel syndrome spectrum diseases[5]. These diverse biological functions are linked to its structural role and interactions with other nucleoporins, impacting both nucleus-cytoplasm communication and key developmental processes[1][4][5][6]. There are currently no documented drugs specifically targeting NUP85, nor established mechanisms of drug action or biomarker usage for therapeutic intervention.

Other names

NUP85NUP75PCNT1FLJ1254985 kDa nucleoporinFROUNTNucleoporin Nup75Nucleoporin Nup85Pericentrin-1NPHS17Nup75nucleoporin 85kDanuclear pore complex protein Nup85nucleoporin Nup75nucleoporin Nup85