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Nuclear pore complex protein Nup93 (NUP93)
- Target
- NUP93
- Molecular classification
- Other (Nucleoporin, nuclear pore complex protein)
01
Overview
Nuclear pore complex protein Nup93 (NUP93) is a core structural component of the nuclear pore complex (NPC), essential for the assembly and function of the NPC, which mediates controlled exchange of macromolecules between the nucleus and cytoplasm[1][2][3]. Nup93 anchors other nucleoporins within the NPC and plays a pivotal role in nuclear pore assembly, maintenance, and, in some tissues, in cell signaling and migration. It is targeted by caspase proteases during apoptosis and is particularly important in renal development, where its deficiency leads to congenital nephrotic syndrome[3]. NUP93 is evolutionarily conserved and homologous to the yeast nucleoporin Nic96p[1].
- Other names
- NIC96KIAA009593 kDa nucleoporinnucleoporin 93kDanuclear pore complex protein Nup93nucleoporin Nup93
02
Biological functions
Nuclear-cytoplasmic transportNuclear pore complex assembly and maintenancePodocyte migration and proliferation via SMAD4 signalingApoptosis (as a caspase substrate)
03
Disease associations
Nephrotic syndrome, type 12Hereditary steroid-resistant nephrotic syndromeOther (implicated in congenital disorders of podocyte function)
04
Safety considerations
Potential implication in kidney disease due to its role in nephrotic syndromeLoss of function mutations cause steroid-resistant nephrotic syndrome
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