Nuclear protein 2, transcriptional regulator (NUPR2)

Nuclear protein 2, transcriptional regulator (NUPR2), also called nuclear protein 1-like (NUPR1L) or P8, is a small nuclear transcription factor involved in the negative regulation of cell proliferation and transcription[3]. It functions as a transcriptional repressor with inhibitory effects at the NUPR1 promoter in a p53-dependent manner, leading to G1 cell cycle arrest and reduced cell viability[3][6]. NUPR2 mutually antagonizes NUPR1, a protumoral factor, and is itself regulated by p53 responsive elements—its expression rises with stress conditions such as serum starvation and is reduced by NUPR1 activity[6]. Unlike NUPR1, which is pro-oncogenic, NUPR2 exhibits tumor-suppressive properties in some contexts (e.g., colorectal cancer cells)[6]. NUPR2 binds known NUPR1 partners (including RING1B) and can form complexes with NUPR1. NUPR2 is associated with Dyskeratosis Congenita and may play roles in stress regulation beyond cancer, but direct evidence for targeting or therapeutic intervention is lacking[3][6].

Other names

NUPR1LP8Nuclear transcriptional regulator 1-like proteinNuclear transcriptional regulator protein 2Nuclear protein 2Nuclear protein, transcriptional regulator, 1-like