Nuclear receptor 2C2-associated protein (NR2C2AP)

Nuclear receptor 2C2-associated protein (NR2C2AP), also known as TRA16, is a nuclear protein encoded by the NR2C2AP gene. It acts as a corepressor of Testicular orphan nuclear receptor 4 (TR4, also called NR2C2) by binding to TR4 and selectively inhibiting its ability to bind DNA response elements and activate target gene transcription. NR2C2AP/TRA16 is predominantly localized in the nucleus, contains 139 amino acids (16 kDa), and shows specificity as a corepressor for TR4, exerting minimal effects on androgen, glucocorticoid, or progesterone receptor transactivation. Its function appears to be the selective repression of TR4-mediated activities, which potentially impact cell signaling in specific tissues, such as testis and possibly in cancer cell contexts. No drugs are directly known to target NR2C2AP, and it is not classified as a canonical therapeutic target.

Other names

TRA16TR4 orphan receptor-associated 16 kDa proteinTR4 orphan receptor associated protein TRA16repressor for TR4 transactivationnuclear receptor 2C2 associated protein

Not a primary drug target; acts as a corepressor protein by inhibiting binding of TR4 (Testicular orphan nuclear receptor 4) to its DNA response element, thereby suppressing TR4-mediated transcriptional activation