Nuclear receptor coactivator 2 (NCoA-2)

Nuclear receptor coactivator 2 (NCoA-2) is a transcriptional coactivator protein encoded by the NCOA2 gene in humans. It acts by interacting with ligand-activated nuclear hormone receptors—including steroid, thyroid, retinoid, and vitamin D receptors—and facilitating transcriptional activation. This protein contains several nuclear receptor interaction domains and intrinsic histone acetyltransferase activity, enabling it to remodel chromatin structure to promote gene transcription. NCoA-2 is essential in regulating genes involved in energy balance, metabolism, and the circadian clock, as well as mediating hormone receptor signaling transduction. It is also a partner in pathological gene fusions associated with certain cancers, underscoring its relevance as a biomarker and potential drug target in oncology and metabolic research.

Other names

NCoA-2SRC-2 (steroid receptor coactivator-2)GRIP1 (glucocorticoid receptor-interacting protein 1)TIF2 (transcriptional intermediary factor 2)hTIF2BHLHE75Class E basic helix-loop-helix protein 75Transcriptional intermediary factor 2

Modulation of hormonal receptor signaling through coactivation; Enhancement of transcriptional activity of nuclear receptors after ligand binding; Indirect chromatin modification and transcription initiation via recruitment to promoter regions.