Nuclear receptor corepressor 1 (NCOR1)

Nuclear receptor corepressor 1 (NCOR1) is a fundamental transcriptional corepressor protein that mediates ligand-independent repression of a variety of nuclear hormone receptors, including thyroid hormone and retinoic acid receptors[1][2][3]. It functions as a scaffold for the assembly of large repressive chromatin complexes by recruiting histone deacetylases, chromatin remodeling factors, and other coregulators to gene promoter regions, thereby condensing chromatin and preventing gene transcription[2][3]. NCOR1 plays a pivotal role in the regulation of metabolism, immune responses, development, and inflammation; dysregulation or loss of NCOR1 function contributes to cardiometabolic diseases, certain cancers, developmental neuropsychiatric disorders, and metabolic syndrome[2][3]. It is considered an important, though as yet not directly druggable, therapeutic target in the modulation of nuclear receptor signaling[3].

Other names

TRAC1N-CoRN-CoR1KIAA1047hCIT529I10thyroid hormone- and retinoic acid receptor-associated corepressor 1PPP1R109protein phosphatase 1, regulatory subunit 109hN-CoR

Ligand-induced release from nuclear receptors enabling gene activation; Promotion of transcriptional silencing via histone deacetylase recruitment; Assembly of multi-protein corepressor complexes at target gene promoters; Control of inflammatory gene programs and metabolic pathways.