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Target intelligence / Profile preview
Nuclear receptor subfamily 1 group D member 2 (NR1D2)
- Target
- NR1D2
- Molecular classification
- Nuclear Receptor, Transcription Factor
01
Overview
Nuclear receptor subfamily 1 group D member 2 (NR1D2), also known as Rev-ErbAβ or REV-ERBβ, is a transcriptional repressor that plays key roles in regulating circadian rhythms, carbohydrate and lipid metabolism, mitochondrial function in skeletal muscle, and inflammatory responses. It belongs to the nuclear hormone receptor family and regulates gene expression by binding to specific DNA motifs, often in conjunction with corepressors. Heme acts as an endogenous ligand that modulates its activity.
- Other names
- Rev-ErbAβREV-ERBβ
02
Mechanism of action
Transcriptional repression via binding to DNA response elements and corepressors; modulation by heme binding
03
Biological functions
Transcriptional regulationRegulation of circadian rhythmsRegulation of carbohydrate metabolismRegulation of lipid metabolismRegulation of mitochondrial functionRegulation of inflammatory responses
04
Disease associations
Atrioventricular septal defectAdvanced sleep phase syndrome familial type 1Metabolic disordersInflammatory diseases
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