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Target intelligence / Profile preview
Nuclear receptor subfamily 1 group F member 3 (RORγ)
- Target
- RORγ
- Molecular classification
- Nuclear Receptor, Transcription factor
01
Overview
Nuclear receptor subfamily 1 group F member 3, also known as RORγ (RORC or RORγt), is a transcription factor belonging to the nuclear receptor family. It is highly expressed in immune cells, particularly Th17 cells, and plays a crucial role in their differentiation. RORγ is also found in the thymus, where it regulates thymocyte development and maturation. Furthermore, it regulates circadian rhythms and is involved in metabolic functions in tissues like the liver. Due to its role in Th17 cell differentiation, dysregulation of RORγ is implicated in autoimmune diseases and inflammation, and it may also play a role in cancer progression.
- Other names
- RORCROR gammaRORγtRetinoic acid-related orphan receptor gamma
02
Mechanism of action
DNA binding at ROREs (ROR response elements), modulating gene expression
03
Biological functions
Transcription regulationTh17 differentiationCircadian rhythm controlImmune system regulationThymocyte developmentMetabolic functions
04
Disease associations
AutoimmunityInflammationCancer
05
Safety considerations
Potential for broad immune dysregulation due to Th17 involvementOff-target effects on other nuclear receptors
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