Nuclear receptor subfamily 2 group C member 2 (NR2C2)

Nuclear receptor subfamily 2 group C member 2 (NR2C2), also known as testicular receptor 4 (TR4), is a member of the nuclear hormone receptor family, functioning as a ligand-activated transcription factor and acting as either a repressor or activator of transcription. NR2C2 regulates diverse biological processes such as development, cellular differentiation, homeostasis, and spermatogenesis, and can modulate gene expression of various nuclear receptor signaling pathways. It has protective roles against oxidative stress and radiation-induced damage. The gene is implicated in disease processes including aging, cancer, and neurodevelopmental abnormalities.

Other names

Testicular receptor 4TR4TAK1hTAK1Orphan nuclear receptor TAK1Orphan nuclear receptor TR4Nuclear hormone receptor TR4orphan nuclear receptor TR4orphan receptor TR4testicular nuclear receptor 4mKIAA4145nuclear receptor subfamily 2, group C, member 2

Repression or activation of transcription of nuclear receptor signaling pathways (e.g., retinoic acid receptor, retinoid X receptor, vitamin D3 receptor, thyroid hormone receptor, estrogen receptor pathways); Modulation of gene expression by binding to hormone response elements