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Target intelligence / Profile preview
Nuclear receptor subfamily 4 group A member 1 (NR4A1)
- Target
- NR4A1
- Molecular classification
- Nuclear receptor, Transcription factor
01
Overview
Nuclear receptor subfamily 4 group A member 1 (NR4A1), also known as Nur77, TR3, and NGFI-B, is an orphan nuclear receptor that functions as a transcription factor and plays diverse roles in cellular physiology and pathology.
- Other names
- NSR4A1Nur77TR3NGFI-B
02
Mechanism of action
NR4A1 typically acts without identified physiological ligands and can bind DNA response elements either alone or with other family members to regulate gene expression. It also influences protein function through nongenomic mechanisms involving cytoplasmic signaling pathways such as CAP1/AC/PKA signaling.
03
Biological functions
Transcription regulationRegulation of cell growthRegulation of cell survivalApoptosisInflammationMetabolismMuscle energeticsT-cell development/functionPlatelet activation
04
Disease associations
CancerCardiovascular diseaseFibrosisNeurological disorders
05
Safety considerations
Context-dependent roles in cancer (tumor suppressor or promoter)
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