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Target intelligence / Profile preview
Nuclear respiratory factor 1 (NRF1)
- Target
- NRF1
- Molecular classification
- Transcription factor
01
Overview
Nuclear respiratory factor 1 (NRF1) is a transcription factor that homodimerizes and regulates the expression of nuclear genes essential for mitochondrial biogenesis, oxidative phosphorylation, cellular growth, respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. NRF1 plays a central role in coordinating communication between nuclear and mitochondrial genomes by directly regulating several nuclear-encoded electron transport chain proteins and indirectly influencing mitochondrial gene expression through activation of factors such as TFAM (mitochondrial transcription factor A).
- Other names
- Nrf-1NRF-1
02
Biological functions
Mitochondrial biogenesisOxidative phosphorylationCellular energy metabolismCellular growthRespirationHeme biosynthesisRegulation of mitochondrial DNA transcription and replicationTelomere transcriptionNeurite outgrowth
03
Disease associations
Neurodegenerative diseasesNeurological disordersNeuropsychiatric disordersCancer
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