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Nuclear RNA export factor 5 (NXF5)
- Target
- NXF5
- Molecular classification
- RNA export factor, RNA binding protein, Member of the NXF/TAP family
01
Overview
Nuclear RNA export factor 5 (NXF5) is a member of the nuclear RNA export factor family which binds RNA and interacts with the RNA nuclear export-associated protein p15/NXT. It is predicted to be involved in the export of mRNA from the nucleus to the cytoplasm, and may also play a role in localizing mRNA within neurons. Most transcript variants are likely subject to nonsense-mediated decay and may not produce functional proteins in vivo, and it is described as a pseudogene in some databases. Disruption of NXF5 was identified in a male patient with syndromic mental retardation, implying a potential developmental role. There are no established drugs or specific disease-modifying interventions linked to NXF5, and it is not widely recognized as a druggable target or receptor.
- Other names
- TAP-like protein 1TAPL-1NXF5
02
Biological functions
RNA bindingmRNA nuclear export (export of mRNA from nucleus to cytoplasm)Possibly involved in polarized cytoplasmic transport and mRNA localization in neurons
03
Disease associations
Potential association with syndromic forms of mental retardation (mental disorders related to X-linked genes)Candidate in Focal Segmental Glomerulosclerosis (limited evidence)
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