Nuclear speckle splicing regulatory protein 1 (NSRP1)

Nuclear speckle splicing regulatory protein 1 (NSRP1) is an RNA-binding protein encoded by the NSRP1 gene on human chromosome 17[3][8][6]. NSRP1 localizes to nuclear speckles, which are dynamic, membrane-less organelles in the nucleus enriched in pre-mRNA splicing factors[1][7]. NSRP1 interacts with other splicing factors such as SRSF1 and SRSF2, and functions as a regulator of alternative splicing through the spliceosome complex[1][3][6]. Loss of function in NSRP1 leads to severe neurodevelopmental disorders with symptoms including delayed milestones, intellectual disability, spasticity, epilepsy, and brain abnormalities comparable to spastic cerebral palsy[1][5]. In cancer biology, NSRP1 downregulation is associated with acquired resistance to CDK4/6 inhibitors in breast cancer, as it mediates alternative splicing events central to the interferon (IFN) signaling pathway and oncogene regulation[2]. NSRP1 has also been implicated in suppression of metastasis in some breast cancer subtypes and may serve as a biomarker for therapeutic response in the context of certain targeted therapies[2]. - NSRP1 is not conventionally exploited as a direct therapeutic target (no known drugs or inhibitory molecules), but its expression and function are clinically relevant in oncology and neurodevelopmental disorders[2][3][4][5].

Other names

CCDC55HSPC095NSrp70NEDSSBAcoiled-coil domain-containing protein 55nuclear speckle-related protein 70