Nuclear transcription factor, X-box binding like 1 (NFXL1)

Nuclear transcription factor, X-box binding like 1 (NFXL1) is a human zinc finger transcription factor with DNA-binding and repressor activity, containing at least two zinc finger motifs and a C-terminal transmembrane domain. It is implicated in the regulation of transcription by RNA polymerase II via sequence-specific DNA binding sites. NFXL1 is expressed in various tissues and is associated with neurodevelopmental disorders (e.g., specific language impairment) and certain cancers (e.g., papillary transitional carcinoma, colon cancer). NFXL1-type proteins contain a distinctive RING finger motif suggesting putative E3 ubiquitin ligase activity, though this has not been fully characterized in humans. There is currently no evidence that NFXL1 serves as a direct therapeutic target, nor are there drugs targeting it or established biomarker applications. Gene location: Chromosome 4 (human). Protein features: 236 amino acids, molecular mass ~27.1 kDa, contains multiple zinc finger motifs which mediate DNA binding and possible repressor functions; might contain a transmembrane domain. Evolutionarily conserved: NFX1-type proteins are broadly found across eukaryotes. NFXL1’s function is most strongly linked to transcriptional regulation in the cell nucleus, and disease associations are principally limited to genetic and transcription-linked abnormalities rather than pharmacological targeting.

Other names

NF-X1-type zinc finger protein NFXL1OZFPhOZFPHOZFPOvarian zinc finger proteinCDZFPURCC5Up-regulated in colon cancer 5