Nuclear transcription factor Y subunit alpha (NFYA)

Nuclear transcription factor Y subunit alpha (NFYA) is an essential component of the highly conserved NF-Y trimeric transcription factor complex, together with NF-YB and NF-YC[1][4][5][2][7]. The NF-Y complex specifically recognizes and binds to CCAAT box motifs found in the promoters of a wide array of genes, acting as a sequence-specific DNA binding factor and a pioneer factor that increases chromatin accessibility for other transcription regulators[1][2][4]. NFYA provides the sequence specificity and regulatory function of the complex, contains a glutamine-rich transactivation domain, and participates in transcriptional regulation critical for cell cycle control, DNA damage response, and proliferation[4][1][5]. While implicated in cancer and other diseases through its regulation of gene expression, NFYA is not a direct therapeutic target in current clinical practice.

Other names

NFYANF-YAHAP2CBF-BCAAT box DNA-binding protein subunit ANuclear transcription factor Y subunit ACBF-ACCAAT-binding transcription factor subunit BHAP2 CCAAT-binding proteinTranscription factor NF-Y, A subunitCCAAT-box DNA binding protein subunit A