Nuclear transcription factor Y subunit beta (NFYB)

Nuclear transcription factor Y subunit beta is a component of the trimeric transcription factor NF-Y, which binds specifically to CCAAT box motifs in the promoters of a wide variety of genes. NFYB, along with subunits NF-YA and NF-YC, forms a highly conserved heterotrimer necessary for specific DNA binding and activation of target gene transcription. The subunit itself contains a histone-like motif and dimerizes with NF-YC before associating with NF-YA. NFYB has a central role in the regulation of gene expression related to cell cycle progression, endoplasmic reticulum stress, and DNA damage response, and it has been implicated in cancer development and chemotherapy resistance, particularly through pathways such as E2F1. The protein itself does not function as a therapeutic target of small molecule drugs or biologics as of current knowledge, but its activity and expression can influence cellular phenotypes relevant to drug resistance and disease progression.

Other names

CBF-AHAP3NF-YBCCAAT-binding factor subunit BHeme activator protein 3