Nuclear transcription factor Y subunit gamma (NFYC)

Nuclear transcription factor Y subunit gamma is one component of a highly conserved heterotrimeric transcription factor (NF-Y) that specifically binds CCAAT motifs in the promoters of target genes. This subunit (gamma, or C) forms a dimer with the beta subunit (NFYB), allowing association with the alpha subunit (NFYA). NF-Y functions in both activation and repression of gene transcription, depending on its cofactors. The B and C subunits share histone-like motifs, supporting a structural and functional analogy to histone proteins. NFYC is encoded on human chromosome 1 and also hosts intronic microRNAs (miR-30c/e) involved in pancreatic islet cell differentiation and phenotype maintenance[1][2][5].

Other names

NF-YCCBF-CCAAT box DNA-binding protein subunit CNuclear transcription factor Y subunit CTransactivator HSM-1/2CCAAT transcription binding factor subunit gammaNuclear transcription factor Y, gammaCCAAT binding factor subunit Chistone H1 transcription factor large subunit 2AHAP5HSMH1TF2ACBFC