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Nucleic Acid (NA)
- Target
- NA
- Molecular classification
- Nucleic Acid, DNA, RNA, mRNA, tRNA, rRNA, Regulatory RNA
01
Overview
Nucleic acids are essential biomacromolecules that store, transmit, and express genetic information. The two primary types are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). They can be targeted directly by small molecules or oligonucleotide-based therapeutics to modulate function or induce degradation, offering therapeutic opportunities across diverse diseases.
- Other names
- Deoxyribonucleic AcidDNARibonucleic AcidRNA
02
Mechanism of action
Modulation of gene expression, induction of nucleic acid degradation, interference with translation/splicing
03
Biological functions
Genetic information storageGenetic information transmissionGene expressionProtein synthesisReplicationTranscriptionTranslationGene regulation
04
Disease associations
CancerInfectionGenetic disordersAutoimmune diseasesNeurodegenerative diseases
05
Safety considerations
Off-target effectsImmune stimulationDelivery challengesToxicity
06
Interacting drugs
Small molecules targeting nucleic acid structures
3 more in the full profile.
07
Biomarkers
mRNA levelsmiRNA levelsSpecific nucleic acid sequence variants
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