Nucleic acid-binding protein 2 (NABP2)

Nucleic acid-binding protein 2 (NABP2), also known as SOSS complex subunit B1 or hSSB1, is a single-stranded DNA-binding protein that plays a critical role in the maintenance of genomic stability[1][2]. It is a component of the SOSS complex, which acts downstream of the MRN complex to facilitate DNA repair and the G2/M cell-cycle checkpoint[1][6]. NABP2 binds single-stranded DNA (preferentially polypyrimidines) mainly through its oligonucleotide/oligosaccharide-binding (OB) fold and is essential for processes such as homologous recombination, regulation of telomeres, maintenance of replication forks, and response to oxidative DNA damage[2]. It is required for efficient homologous recombination-dependent repair of double-strand breaks and participates in ATM-dependent signaling pathways, thereby contributing to cell-cycle checkpoint activation and DNA damage response[1][2]. NABP2 dysfunction can lead to impaired DNA repair and is implicated in diseases related to genomic instability, including cancer[1][2].

Other names

SOSS complex subunit B1OBFC2BSSB1hSSB1SOSS-B1LP3587MGC2731Oligonucleotide/oligosaccharide-binding fold-containing protein 2BSensor of single-strand DNA complex subunit B1Sensor of ssDNA subunit B1Single-stranded DNA-binding protein 1single strand DNA-binding protein 1