Nucleic acid encapsulation and intracellular delivery

Nucleic acid encapsulation and intracellular delivery refers to a class of technologies designed to protect nucleic acids (DNA, RNA) from enzymatic degradation in the bloodstream, enhance their uptake into cells, and promote their release into the cytoplasm or nucleus for therapeutic effect. These strategies use non-viral systems such as lipid nanoparticles, polymers, or inorganic materials to encapsulate and transport the genetic material through biological barriers. These delivery systems are essential for the efficacy of gene therapies and nucleic acid-based drugs, addressing key challenges such as poor cellular uptake, rapid clearance, low stability, and the need for endosomal escape. However, they represent delivery strategies rather than discrete molecular therapeutic targets, and thus should not be categorized as canonical molecular entities.

Other names

nucleic acid deliverygene deliveryRNA deliveryDNA deliverynucleic acid nanoparticle deliverynon-viral gene delivery