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Target intelligence / Profile preview
Nucleobindin-2 (NUCB2)
- Target
- NUCB2
- Molecular classification
- EF-hand calcium-binding protein, Precursor protein
01
Overview
Nucleobindin-2 (NUCB2) is an evolutionarily conserved EF-hand calcium-binding protein that serves both structural/regulatory functions within cells—especially regarding calcium homeostasis—and acts as a precursor for bioactive peptides like nesfatin-1 involved centrally/peripherally in appetite suppression/metabolic control. Its multifaceted roles extend into cancer biology where it can either promote or suppress tumorigenesis depending on context—a property under active investigation for therapeutic targeting or biomarker development.
- Other names
- DNA-binding protein NEFAGastric cancer antigen Zg4PrepronesfatinNesfatin-1
02
Mechanism of action
N/A
03
Biological functions
Calcium homeostasisAppetite regulationEnergy balanceBlood pressure regulationPrecursor to nesfatin peptides
04
Disease associations
CancerUsher syndrome
05
Safety considerations
Complex role in cancer (sometimes promoting metastasis or tumor progression while at other times inhibiting it)More research is needed for definitive disease associations
06
Biomarkers
NUCB2Nesfatin-1
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