Nucleolar and spindle-associated protein 1 (NUSAP1)

Nucleolar and spindle-associated protein 1 (NUSAP1) is a microtubule-associated protein essential for mitotic progression, spindle assembly, chromosome segregation, and cell cycle regulation[1][3][4][5]. It binds directly to microtubules, promotes spindle formation, and participates in chromosome attachment during mitosis[4][5]. NUSAP1 is tightly regulated, cycling in expression and undergoing post-translational modifications such as SUMOylation to modulate its function[3]. High expression of NUSAP1 is documented in multiple cancers, correlating with poor prognosis and increased DNA damage repair via interaction with RAD51[1]. Knockdown or inhibition suppresses tumor cell proliferation and sensitizes cells to drugs like fludarabine and ibrutinib[1]. NUSAP1 is also a marker for cell proliferation, is involved in apoptosis and cell migration, and has been implicated in developmental disorders when mutated or dysregulated[5]. Its potential as a therapeutic target lies in its pivotal mitotic functions and its oncogenic activity in various malignancies.

Other names

ANKTBM-037PRO0310NuSAPFLJ13421LNPSAPLBM037PRO0310p1Q0310nucleolar protein ANKT

Sensitization of tumor cells to chemotherapeutics by NUSAP1 knockdown; Regulation of DNA damage repair pathway via RAD51 binding; Microtubule stabilization and spindle organization interference