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Nucleolar protein 11 (NOL11)
- Target
- NOL11
- Molecular classification
- Other (ribosome biogenesis factor, nucleolar protein, small subunit processome component)
01
Overview
Nucleolar protein 11 (NOL11) is a metazoan-specific, nucleolus-localized protein that plays a critical role in the early stages of ribosome biogenesis. It is incorporated into the small subunit (SSU) processome, interacting with proteins such as hUTP4/Cirhin, and is required for both optimal pre-rRNA processing and transcription. NOL11 is essential for maintaining proper nucleolar morphology, and its depletion in cells leads to reduced 18S rRNA maturation, impaired rDNA transcription, and nucleolar stress responses, including p53 stabilization and apoptotic phenotypes in developing organisms. There are no drugs directly targeting NOL11, and it is not considered a classic therapeutic target like enzymes or receptors.
- Other names
- L14DKFZP586L0724Nucleolar protein 11NOL11
02
Biological functions
Ribosome biogenesispre-rRNA processingrDNA transcription
03
Disease associations
Other (implicated in ribosomopathies such as North American Indian childhood cirrhosis, craniofacial malformations due to developmental defects, nucleolar stress-induced p53 stabilization and apoptosis in model organisms)
04
Safety considerations
Loss of function leads to nucleolar stress, abnormal nucleolar morphology, impaired ribosome biogenesis, and p53-mediated apoptosis in development
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