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Target intelligence / Profile preview
Nucleolar protein 16 (NOP16)
- Target
- NOP16
- Molecular classification
- Other, Nucleolar protein involved in ribosomal biogenesis
01
Overview
Nucleolar protein 16 (NOP16) is a nucleolar-localized protein involved in the biogenesis of the large 60S ribosomal subunit and RNA binding[1][2][6][7]. Its expression is induced by estrogens and Myc, and it is considered a marker for poor prognosis in breast cancer[2]. NOP16 has also been implicated in the progression of hepatocellular carcinoma and the epithelial-mesenchymal transition (EMT) via the Keap1-Nrf2 signaling pathway[4][5]. There are several transcript variants due to alternative splicing. Although NOP16 is involved in critical cellular processes and linked to cancer biology, it is not generally classified as a classical therapeutic target such as a receptor, enzyme, transporter, or transcription factor.
- Other names
- CGI-117HSPC111HSPC185LOC51491HBV pre-S2 trans-regulated protein 3hypothetical protein HSPC111
02
Biological functions
Ribosome biogenesisRNA bindingCell proliferation
03
Disease associations
Cancer (notably breast cancer, hepatocellular carcinoma)Other
04
Biomarkers
Indicator of poor patient survival in breast cancer
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