Nucleolar protein 4 (NOL4)

Nucleolar protein 4 (NOL4) is a nucleolar-localized protein encoded by the NOL4 gene in humans. It is predicted to enable RNA binding activity and is involved in various cellular processes, primarily within the nucleolus[1][2][5]. NOL4 has been identified as a methylation target in several cancers, including cervical and head and neck cancer, indicating a possible role in tumorigenesis[3]. Though implicated in cancer, it is not established as a classical therapeutic target (such as a receptor, enzyme, or transporter). NOL4 is associated with certain neuroendocrine tumors, but detailed mechanisms and therapeutic targeting remain to be defined[1][3].

Other names

NOLPHRIHFB2255CT125Nucleolar-localized proteinCancer/testis antigen 125nucleolar localized protein