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Target intelligence / Profile preview
Nucleolar protein 8 (NOL8)
- Target
- NOL8
- Molecular classification
- Other (nucleolar protein; contains RNA recognition motif/RRM)
01
Overview
Nucleolar protein 8 (NOL8) is a nucleolar-localized protein encoded by the *NOL8* gene in humans. It possesses an N-terminal RNA recognition motif (RRM) and participates in nucleic acid and protein binding. NOL8 is involved in cell growth, acting through interactions with Ras-related GTP-binding proteins, and plays a critical role in the survival of diffuse-type gastric cancer cells. It also serves as a nucleolar anchoring protein for DDX47, and may be implicated in post-transcriptional gene regulation and ribosome biogenesis, particularly relevant to cancer cell biology. While involved in important cellular functions and cancer biology, NOL8 is not considered a therapeutic target, receptor, enzyme, or transporter, and there are currently no known drugs that interact with it.
- Other names
- C9orf34NOP132FLJ20736Nop132bA62C3.3bA62C3.4nucleolar protein Nop132
02
Mechanism of action
no known mechanism of action for drugs targeting NOL8, as it is not a recognized therapeutic target
03
Biological functions
RNA binding (contains an N-terminal RNA recognition motif)Nucleic acid bindingProtein bindingNucleolar anchoring (interacts with DDX47)Cell growth regulation (binds Ras-related GTP-binding proteins, may regulate gene expression and ribosome biogenesis, especially in the context of cancer cells)
04
Disease associations
Cancer (specifically diffuse-type gastric cancer, essential for survival of these cells)Bloom syndrome association
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