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Nucleolar protein interacting with the FHA domain of MKI67 (NIFK)
- Target
- NIFK
- Molecular classification
- Other (nucleolar phosphoprotein), RNA-binding protein
01
Overview
Nucleolar protein interacting with the FHA domain of MKI67 (NIFK) is a human nucleolar phosphoprotein encoded by the MKI67IP gene. NIFK contains an RNA recognition motif (RRM) at its N-terminus and a domain that binds to the forkhead-associated (FHA) domain of the Ki-67 antigen, a protein involved in cell proliferation. The interaction between NIFK and Ki-67 is phosphorylation-dependent, involving sequential modification by CDK1 and GSK3 kinases. NIFK is believed to play a role in mitosis and cell cycle progression, likely through its interactions with RNA and the Ki-67 antigen. While related to cellular proliferation and studied in the context of cancer, NIFK itself is not a direct disease marker or drug target. Its gene is located on chromosome 2.
- Other names
- MKI67 FHA domain-interacting nucleolar phosphoproteinMKI67IPNOPP34Nopp34hNIFKNucleolar phosphoprotein Nopp34Nucleolar protein interacting with the FHA domain of pKi-67
02
Biological functions
Cell cycle regulationMitosisRNA binding
03
Disease associations
Cancer (NIFK interacts with Ki-67, which is a well-known proliferation marker used in cancer pathology, but NIFK itself is not a common direct disease target)Other (potential involvement through cell cycle regulation, but no distinct direct disease annotation)
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