Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Nucleolar protein with MIF4G domain 1 (NOM1)
- Target
- NOM1
- Molecular classification
- Other, nucleolar protein, protein phosphatase 1 regulatory subunit
01
Overview
Nucleolar protein with MIF4G domain 1 (NOM1) is a nucleolar protein containing MIF4G and/or MA3 domains, involved in RNA processing and pre-rRNA maturation by interacting with DEAD-box RNA helicases and functioning as a scaffold for ribosome biogenesis. NOM1 also acts as a regulatory subunit for protein phosphatase 1 (PP1), mediating PP1 recruitment to the nucleolus via a conserved RVXF motif and nucleolar localization sequence. In addition, NOM1 is implicated in signaling pathways with the insulin-like growth factor 1 receptor (IGF1R) and participates in the regulation of cell growth, proliferation, and nucleolar function. NOM1 is not currently considered a direct therapeutic drug target nor are there any approved drugs or established biomarkers directly targeting this protein.
- Other names
- C7orf3PPP1R113SGD1SGD1 homologprotein phosphatase 1 regulatory subunit 113nucleolar MIF4G domain-containing protein 1
02
Biological functions
RNA processingpre-rRNA processingribosome biogenesisprotein translationnucleolar targetingprotein phosphatase 1 (PP1) targeting/regulationcell growth and proliferation signaling
03
Disease associations
Cancer (some evidence from expression/mutation studies and IGF1R pathway involvement)Other (not a primary disease target but implicated in pathways relevant to disease)
Beyond the preview
Go deeper on Nucleolar protein with MIF4G domain 1 (NOM1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Nucleolar protein with MIF4G domain 1 (NOM1).