Target intelligence / Profile preview

Nucleolin (NCL)

Target: NCL
Molecular classification: RNA-binding protein, DNA-binding protein

Overview

Nucleolin is a highly abundant, multifunctional protein primarily localized in the nucleolus of eukaryotic cells. It plays critical roles in ribosome biogenesis, chromatin structure regulation, and acts as a receptor for growth factors and viruses. Its involvement in cancer and viral infection makes it a potential therapeutic target.

Other names: C23NSR1

Mechanism of action

Curcumol binds directly to nucleolin, leading to its degradation, thereby exerting anti-cancer effects.

Biological functions

Ribosome biogenesisrRNA processingChromatin remodelingTranscription regulationViral entry receptor

Disease associations

CancerInfection

Interacting drugs

Curcumol

2 more in the full profile.

Biomarkers

Nucleolin expression level (cancer)

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