Nucleophile-reactive site

A "nucleophile-reactive site" describes any atom or region within a molecule that is susceptible to attack by a nucleophile, an electron-rich chemical species that donates a pair of electrons to form a new covalent bond. Nucleophile-reactive sites are found in a wide range of molecules and are central to mechanisms in organic chemistry, such as substitution and addition reactions. In the context of biology or drug discovery, referring generically to a "nucleophile-reactive site" does not define a specific molecular target or class of drug target; instead, it describes a class of reactive chemical functionality. Therefore, "nucleophile-reactive site" is not recognized as a canonical therapeutic target.

Other names

nucleophile-reactive centernucleophilic target sitesite susceptible to nucleophilic attack

Covalent modification of a target by a nucleophile; Substitution reactions (e.g., nucleophilic substitution); Alkylation, acylation, etc., via nucleophilic attack