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Target intelligence / Profile preview
Nucleophosmin (NPM1)
- Target
- NPM1
- Molecular classification
- RNA Binding Protein, Histone Chaperone, Phosphoprotein
01
Overview
Nucleophosmin/NPM1 is an essential multifunctional protein involved primarily in ribosome biogenesis/histone chaperoning/genomic stability/cell cycle control/apoptosis regulation. It achieves these functions through dynamic subcellular localization regulated by post-translational modifications. Its dysregulation—by mutation or overexpression—is strongly implicated especially in hematologic malignancies like AML but also many solid cancers.
- Other names
- B23NO38Numatrin
02
Biological functions
Ribosome BiogenesisHistone Chaperone ActivityGenomic StabilityDNA RepairCell Cycle RegulationApoptosis RegulationRNA BindingEndoribonuclease Activity
03
Disease associations
Acute Myeloid Leukemia (AML)Solid TumorsCancer
04
Safety considerations
Context-dependent oncogenic or tumor-suppressor roleAberrant cytoplasmic localization associated with disease
05
Biomarkers
NPM1 mutations (AML)NPM1 expression level (tumors)Cytoplasmic localization of NPM1
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