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Nucleophosmin 1 pseudogene 13 (NPM1P13)

Target: NPM1P13
Molecular classification: Other (Pseudogene)

Overview

Nucleophosmin 1 pseudogene 13 (NPM1P13) is a human genomic locus classified as a pseudogene, showing high sequence similarity to the functional Nucleophosmin 1 (NPM1) gene but not producing a functional protein[5]. There is no evidence of its transcription or translation, nor of any function in health or disease. Its primary significance lies in its potential to be misattributed as the real NPM1 gene, which is an important biomarker and therapeutic target in several cancers, especially acute myeloid leukemia.

Mechanism of action

None. No mechanisms of action are described for pseudogenes like NPM1P13.

Biological functions

None established. Pseudogenes generally have no protein-coding function, although some pseudogenes may have regulatory roles (e.g., as RNA), but no evidence is published for biological function of NPM1P13

Disease associations

None known. There are no direct disease associations for NPM1P13. This contrasts with the functional NPM1 protein, which is well-known in the context of acute myeloid leukemia and other cancers

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