Nucleophosmin 1 pseudogene 14 (NPM1P14)

Nucleophosmin 1 pseudogene 14 (NPM1P14) is an annotated processed pseudogene related to the NPM1 gene family, listed in gene databases as a non-coding genomic sequence that does not encode a functional protein. Processed pseudogenes like NPM1P14 typically arise from the reverse transcription of mRNA from a functional gene and insertion back into the genome, but they generally lack regulatory elements required for expression and do not produce functional protein products. NPM1P14, specifically, has no documented role in cellular physiology, signaling pathways, or disease. The functional gene in this family, nucleophosmin 1 (NPM1), is an important marker and driver in acute myeloid leukemia, but this is distinct from the pseudogene NPM1P14[1]. There are no known drugs targeting NPM1P14, no role as a biomarker, and no therapeutic safety concerns because it does not function as a protein-coding gene or receptor. While the NPM1 gene itself is a prominent target in cancer research (especially in AML)[1], NPM1P14 is a pseudogene and not a viable or meaningful drug target. If you are seeking information about the functional nucleophosmin 1 protein (NPM1), consult canonical resources for NPM1, not NPM1P14.

Other names

NPM1P14nucleophosmin pseudogene 14