Nucleophosmin 1 pseudogene 21 (NPM1P21)

Nucleophosmin 1 pseudogene 21 (NPM1P21) is a processed pseudogene related to the NPM1 gene, which encodes nucleophosmin, a multifunctional nucleolar phosphoprotein involved in ribosome biogenesis, cell proliferation, and genomic stability[4][1]. However, as a pseudogene, NPM1P21 lacks the capacity to encode a functional protein and thus does not play an active biological role; it is not established as a therapeutic target, nor does it serve as a biomarker or interact with drugs. The NPM1 gene and its protein product are clinically relevant in hematologic cancers such as acute myeloid leukemia (AML), but the pseudogene NPM1P21 is distinct and unrelated to these disease mechanisms or drug targets[5][2]. Pseudogenes are often denoted by supplementary numbers (e.g., “pseudogene 21”) and are non-functional gene copies; they do not produce proteins or act as receptors, enzymes, or signaling molecules.

Other names

NPM1P21