Nucleophosmin 1 pseudogene 23 (NPM1P23)

**Nucleophosmin 1 pseudogene 23 (NPM1P23)** is classified as a processed pseudogene and is not believed to encode a functional protein[3]. Pseudogenes are genomic DNA sequences similar to normal genes but are non-functional; they may arise by duplication or retrotransposition, often bearing resemblance to their parent gene but lacking the ability to produce an active product[3][4]. NPM1P23 is homologous to the functional nucleophosmin 1 (NPM1) gene, which itself encodes a nucleolar phosphoprotein involved in ribosome biogenesis, cell proliferation, and genomic stability[1][5]. However, there is no evidence that NPM1P23 has biological activity, is expressed as a protein, or serves as a therapeutic target. The designation "pseudogene" and the lack of experimental evidence for functional RNA-mediated regulatory roles mean it is not classified under canonical molecular targets such as receptors, enzymes, channels, or transporters[3][4]. Accordingly, there are no known drugs, mechanisms of action, disease roles, biomarker relevance, or safety concerns associated with NPM1P23. **Notes:** - This entry is neither a receptor, enzyme, nor any other canonical molecular target used therapeutically—rather, it is a processed pseudogene, generally thought to be non-functional in protein coding[3][4]. - As pseudogenes can occasionally act as regulatory elements (such as mRNA decoys) in some contexts, there is emerging interest in studying them for possible roles in gene regulation and disease, but no such functions are reported for NPM1P23 specifically[2][6]. - It is not a known biomarker, nor associated with clinical diseases or therapeutic modulation.

Other names

nucleophosmin (nucleolar phosphoprotein B23, numatrin) pseudogenenucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 23NPM1P23