Nucleophosmin 1 pseudogene 3 (NPM1P3)

Nucleophosmin 1 pseudogene 3 (NPM1P3) is a processed pseudogene related to the functional NPM1 gene, which encodes nucleophosmin, a multifunctional nucleolar protein involved in ribosome biogenesis, cell cycle regulation, and genomic stability[1][3][5][7]. As a pseudogene, NPM1P3 does not encode a functional protein and is not implicated as a therapeutic target, biomarker, or disease modulator. Information on NPM1P3 is scarce, as research and clinical interest are centered on the functional NPM1 gene and its variants, which play well-defined roles in cancer biology, especially acute myeloid leukemia[6]. There is no established role for NPM1P3 in normal or disease biology, drug interactions, or as a therapeutic biomarker. NPM1P3 is not a protein-coding gene and therefore not a receptor, enzyme, transporter, or other classical drug target type. The designation “pseudogene” means it is a nonfunctional segment of DNA resembling the NPM1 gene, likely arising from gene duplication or retrotransposition. The main target of biomedical interest is the functional NPM1 gene (Nucleophosmin 1)[1][3][5][6][7]. There is no evidence in the literature that NPM1P3 is involved in disease or targeted by drugs. Nucleophosmin 1 pseudogene 3 (NPM1P3) is a nonfunctional genetic element and not considered a molecular target in drug discovery or biomedical research. There is nothing inherently therapeutic or actionable about this entity; if a functional or disease-related NPM1 target is intended, information about the NPM1 gene/protein should be sought instead.

Other names

NG3-3Nucleophosmin pseudogene 3