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Nucleophosmin 1 pseudogene 4 (NPM1P4, also called NG4-5) is a human non-functional gene classified as a pseudogene. It shares sequence similarity with the active nucleophosmin 1 (NPM1) gene family but does not encode a functional protein. There are no known direct biological functions or disease associations for NPM1P4. The canonical NPM1 protein (not the pseudogene) is a multifunctional nucleolar protein involved in ribosome biogenesis, genomic stability, apoptosis, and is a well-established oncogenic factor in leukemia and other malignancies[1][2][3][5][7]. NPM1P4 itself has no reported role in cellular or therapeutic biology.
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