Nucleophosmin 1 pseudogene 40 (NPM1P40)

Nucleophosmin 1 pseudogene 40 (NPM1P40) is a processed pseudogene of the nucleophosmin 1 (NPM1) gene, which encodes an abundant nucleolar protein implicated in ribosome biogenesis, genomic stability, and apoptosis[1][3][5]. Pseudogenes like NPM1P40 are generally non-coding DNA segments that resemble the parental gene but have lost coding capacity due to mutations or truncations. Emerging research suggests that transcribed pseudogenes can regulate their parental genes through RNA-based mechanisms, such as acting as microRNA decoys (competing endogenous RNAs, ceRNAs)[2]. While some pseudogenes—including PTENP1 and KRAS1P—have demonstrated such regulatory activity in cancer biology[2], there is currently no direct evidence that NPM1P40 itself is biologically active or therapeutically relevant. The parental NPM1 protein is of major clinical importance in oncology, especially in acute myeloid leukemia, where its mutations serve as diagnostic and prognostic markers[3][5]. NPM1P40, by contrast, is considered a non-coding locus with potential, but unproven, regulatory effects[2][4]. **Key Distinction:** NPM1 (not NPM1P40) is an established protein, a histone chaperone involved in cell growth, apoptosis, and genome stability, and is mutated in some cancers[1][3][5]. NPM1P40 is its pseudogene, which does not function as a receptor, enzyme, or direct pharmacologic target. If you require structured information for the protein Nucleophosmin 1 (NPM1), it is a well-characterized oncogenic and tumor suppressor-associated protein relevant in cancer biology[1][3][5], but this entry is for its pseudogene, NPM1P40.

Other names

Nucleophosmin (nucleolar phosphoprotein B23, numatrin) pseudogenenucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 40NPM1P40

Not applicable; as a pseudogene, it does not serve as a classic druggable target. If any effect exists, it would be through microRNA sequestration influencing NPM1 expression