Nucleophosmin 1 pseudogene 50 (NPM1P50)

Nucleophosmin 1 pseudogene 50 (NPM1P50) is a processed pseudogene derived from the parental NPM1 gene, which encodes the nucleophosmin (NPM, also known as B23, numatrin) protein, a multifunctional nucleolar phosphoprotein that plays key roles in ribosome biogenesis, genomic stability, and regulation of the cell cycle. Unlike the functional NPM1 gene, NPM1P50 is noncoding and typically does not produce a functional protein due to mutations or lack of necessary regulatory sequences. Processed pseudogenes are formed via retrotransposition and integrate randomly in the genome, lacking introns and often being transcriptionally silent. While some pseudogenes can be transcribed and play regulatory roles—such as acting as competing endogenous RNAs or miRNA sponges—no evidence currently links NPM1P50 to such functions.

Other names

Nucleophosmin (nucleolar phosphoprotein B23, numatrin) pseudogene 50nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 50NPM1P50

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