Nucleoporin 35 (NUP35)

Nucleoporin 35 (NUP35) is a member of the nucleoporin family, localized to the nuclear rim as a core structural component of the nuclear pore complex (NPC), which regulates molecular trafficking between the nucleus and cytoplasm in eukaryotic cells[1][3][4][5][6]. NUP35 has two membrane binding regions and interacts with other nucleoporins and nuclear transport factors as part of NPC architecture[5][6]. In addition to its essential nuclear transport roles, NUP35 is dynamically involved in cell cycle progression and has specialized functions in spindle assembly and chromosome alignment during oocyte meiosis, likely in a regulated (phosphorylated) form[2]. There is no evidence that NUP35 is a direct therapeutic target or that drugs specifically modulate its activity, and it is not associated with established clinical biomarkers or safety concerns.

Other names

MP44NUP53Mitotic phosphoprotein 44Nuclear pore complex protein Nup5335 kDa nucleoporinNucleoporin NUP53MP-44NP44NUP35