Nucleoporin 37 (NUP37)

Nucleoporin 37 (NUP37) is a scaffold protein that is a component of the Nup107-160 subcomplex (also called the Y-complex) of the nuclear pore complex (NPC)[1][3][4]. The NPC is essential for the transport of macromolecules between the cytoplasm and the nucleus, regulating nucleocytoplasmic exchange, and also plays key roles in mitosis, chromosome segregation, and cell cycle progression[1][3][5]. NUP37 binds to other nucleoporins, especially Nup120 (NUP160 in humans), serving a stabilizing/scaffolding role necessary for proper NPC assembly and function[3][4]. NUP37 is required for proper kinetochore-microtubule interactions and normal chromosome segregation during mitosis[1]. It is also involved in early embryonic development and oocyte maturation, in part through the regulation of YAP-TEAD signaling, which affects cell proliferation and developmental competence[5]. Emerging evidence indicates that NUP37 is upregulated in certain cancers such as breast and liver cancer and may serve an oncogenic role, associating with tumor cell growth, migration, and poor clinical prognosis[2]. Loss-of-function mutations can lead to neurodevelopmental diseases such as primary autosomal recessive microcephaly[1]. Currently, there are no known drugs that specifically target NUP37, and it is not a conventional therapeutic target (receptor, enzyme, transporter). Targeting NUP37 poses significant safety risks given its essential role in basic cellular and developmental functions[1][5].

Other names

Nucleoporin Nup37p37MGC5585FLJ22618Nup107-160 subcomplex subunit Nup37MCPH24nucleoporin 37kDa