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Nucleoporin 43 (NUP43)
- Target
- NUP43
- Molecular classification
- Other (nucleoporin), Scaffold protein (as part of nuclear pore complex), β-propeller domain protein
01
Overview
Nucleoporin 43 (NUP43) is a member of the Nup107-160 subcomplex of the nuclear pore complex (NPC), a large macromolecular structure embedded in the nuclear envelope that controls the exchange of macromolecules between the nucleus and cytoplasm[1][2][3][4]. NUP43 contains a WD40 repeat domain and a seven-bladed β-propeller architecture, contributing to the scaffold’s stability and assembly of the NPC[4]. It is essential for proper kinetochore microtubule attachment and accurate chromosome segregation during cell division[1]. High NUP43 expression is correlated with poor survival in breast cancer and resistance to the tyrosine kinase inhibitor imatinib in leukemia, suggesting disease relevance[1]. NUP43 is part of various cellular and disease processes but is not currently a direct therapeutic target.
- Other names
- Nucleoporin Nup43NUP43Nup107-160 subcomplex subunit Nup43bA350J20.1FLJ13287p42nucleoporin 43 kDa
02
Biological functions
Nuclear-cytoplasmic transport regulationNPC assemblyChromosome segregation during cell divisionCell cycle progression
03
Disease associations
Cancer (overexpression linked to poor outcomes in breast cancer[1])Leukemia (promotes cell proliferation and imatinib resistance in CML[1])Cardiovascular disease (variants associated[1])Neuropsychiatric disorder (associated with ADHD[1])
04
Biomarkers
NUP43 expression level (in breast cancer, high expression correlates with poor prognosis[1])
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