Nucleoprotein (None)

Nucleoproteins are complexes of nucleic acids (DNA or RNA) with proteins, primarily located within the cell nucleus. In the context of Systemic Lupus Erythematosus (SLE), nucleoproteins serve as major autoantigens. Autoantibodies against nucleoproteins form immune complexes, contributing to inflammation and tissue damage. Therapeutic strategies aim to suppress the autoimmune response against these complexes, often by targeting B cells, T cells, or inflammatory cytokines like type I interferon.

Other names

DNA-protein complexRNA-protein complexLupus cell factor target

Varies depending on the therapeutic agent. Examples include B-cell depletion, inhibition of interferon signaling, and suppression of immune cell activity.