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Target intelligence / Profile preview
Nucleoside diphosphate kinase (NDK or NDPK)
- Target
- NDK or NDPK
- Molecular classification
- Enzyme, Transferase, Phosphotransferase
01
Overview
Nucleoside diphosphate kinase is a central metabolic enzyme responsible for maintaining nucleotide balance within cells by transferring phosphate groups between various nucleotide substrates via a unique ping-pong mechanism involving transient phosphorylation at its active site histidine residue. It plays additional roles beyond metabolism including cell signaling modulation and disease association through both enzymatic activity and protein-protein interactions.
- Other names
- NDPK
02
Mechanism of action
Phosphorylation of nucleoside diphosphates to produce nucleoside triphosphates via a ping-pong mechanism.
03
Biological functions
Nucleotide homeostasisProtein synthesisSignal transductionLipid biosynthesisPolysaccharide synthesisDNA replicationDNA repairMetastasis suppression/promotionCytoskeletal dynamicsEndocytosisMembrane remodelingDNA bindingInsulin release regulationErythroid lineage development
04
Disease associations
CancerDiabetes-like vascular pathology
05
Safety considerations
Dysregulation can be associated with disease states
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